Referencias

Compartimos estudios que sustentan la aplicación de soluciones basadas en medicina de precisión – programas integrales de salud, diagnósticos avanzados, terapias celulares regenerativas, y suplementación intravenosa – bajo la supervisión médica adecuada para no generar ni inferir falsas expectativas.
Icono de Programas de Salud del Rendimiento (PSR).

Programas de Salud del Rendimiento (PSR)

Contacto
Age Management
  1. Campanelli, Linda, C., Ph.D. “Theories of Aging.” Theories and Psychosocial Aspects of Aging (1) 3-13.
  2. Rotstein, M. (Ed). Review of Biological Research in Aging, vol. 4. New York: Wiley-Liss, 1990.
  3. Capurso, A., Panza, F., Solfrizzi, V., Torres, F., Carpuso, C., Mastroianni, F., Del Parigi, A. “Age-related cognitive decline: Evaluation and prevention strategy.” Recenti Prog Med 2009; 91: 127-34.
  4. Chan, K.M., Raja, A.J., Strohschein, F.J., Lechelt, K. “Age-related changes in muscle fatigue resistance in humans.” Can J Neurol Sci 2000; 27: 220-8.
  5. Chauhan, J., Hawrysh, Z.J., Gee, M., Donald, E.A., Báu, T.K. “Age-related olfactory and taste changes and interrelationships between taste and nutrition.” J Am Diet Assoc 1987: 87: 1543-50.
  6. Fleg, J.L. “Alterations in cardiovascular structure and function with advancing age.” Am J Cardiologías 1986; 57: 33C-44C.
  7. Hayflick, L. How and Why We Age. New York: Ballantine Books, 1994; pp. 222-262.
  8. Piers, L.S., Soares, M.J., McCormack, L.M., O’Dea, K. “Is there evidence for an age-related reduction in metabolic rate?” J Appl Physiol 1998; 85: 2196-204.
  9. Sharma, Ramesh. “Theories of Aging,” in Physiological Basis of Aging and Geriatrics. Florida: CRC Press, 1994; 37-44.
  10. Sonneborn, T. “The Origin, Evolution, Nature, and Causes of Aging,” in Behnke, J., Since, C., and Moment, G. (Des), The Biology of Aging. New York: Plenum Press, 1979; p. 341.
  11. Van Cauter, E., Leproult, R., Plat, L. “Age-related changes in slow wave sleep and REM sleep and relationship with growth hormone and cortisol levels in healthy men.” JAMA 2000; 284: 861-8.

Nutrición precisa
  1. O’Keefe JH, Gheewala NM, O’Keefe JO (2008) Dietary strategies for improving post-prandial glucose, lipids, inflammation, and cardiovascular health. J Am Coll Cardiologías 51: 249-255.
    Sesso HD, Paffenbarger Jr. RS, Lee IM (2001) Alcohol consumption and risk os prostate cancer: The Harvard Alumni Health Study. Int J of Epi 30:749-755.

Optimización metabólica y hormonal
  1. Butler RN, Fossel M, Mitchell H, Heward CB, Olshansky SJ, Perls TT, Rothman DJ, Rothman SM, Warner HR, West MD, and Wright WF (2002) Is there an anti-aging medicine? J of Gerontology Series A: Bio Sci Med Sci (57):B333-B3385.
  2. Das UN (2006) Exercise and inflammation. The Euro Heart J. 27(11): 1385.

Suplementación nutricional
  1. Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C (2007) Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: Systematic review and meta-analysis. JAMA 297 (8): 842-857
  2. Willett WC, Stampfer MJ (2001) Clinical practice. What vitamins should I be taking, doctor? N Engl J Med 345 (25):1819-1824.
Icono de diagnósticos avanzados.

Diagnósticos avanzados

Contacto
Medición de telómeros
  1. Atzmon, G., M. Cho, R. M. Cawthon, et al. “Evolution in Health and Medicine Sackler Colloquium: Genetic Variation in Human Telomerase Is Associated with Telomere Length in Ashkenazi Centenarians.” Proceeding of the National Academy of Sciences (January 26, 2010): Suppl.1:1710-1717.
  2. Andrews, William. “Telomerase Activation: The Future of Anti-Aging Medicine.” Presentation at the American Academy of Anti-Aging Conference, September 11, 2009. www.youtube.com/watch?v=F3breSdCUXA&feature=related
  3. Babizhayev, M. A., E. L. Savel’yeva, S. N. Moskvina, et al. “Telomere Length Is a Biomarker of Cumulative Oxidative Stress, Biologic Age, and Independent Predictor of Survival and Therapeutic Treatment Requirements Associated with Smoking Behavior.” American Journal of Therapeutics (March 29, 2010). http://journals.lww.com/americantherapeutics/Abstract/publishahead/Telomere_Length_is_a_Biomarker_of_Cumulative.99779.aspx.
  4. Blackburn, Elizabeth. “Stress, Telomeres and Telomerase in Humans.” University of California–San Francisco, Department of Biochemistry and Biophysics. http://ibioseminars.org/blackburn/blackburn3.shtml.
  5. Epel,E. S., E. H. Blackburn, J. Lin, et al. “Accelerated Telomere Shortening in Response to Life Stress.” Proceedings of the National Academy of Sciences of the United States of America (September 28, 2004). www.pnas.org/content/101/49/17312.
  6. Ocampo, C. “Telomere Talk: The Nutrition Connection.” Journal of Nutrition for the Eldery 29, no. 1 (January 2010): 110–111.
Icono de terapias regenerativas.

Terapias celulares regenerativas

Contacto
Terapias con células madre mesenquimales
  1. A Randomized, Placebo-Controlled Trial of Human Umbilical Cord Blood Mesenchymal Stem Cell Infusion for Children With Cerebral Palsy
  2. Al Demour S, Jafar H, Adwan S, AlSharif A, Alhawari H, Alrabadi A, Zayed A, Jaradat A, Awidi A. Safety and Potential Therapeutic Effect of Two Intracavernous Autologous Bone Marrow Derived Mesenchymal Stem Cells injections in Diabetic Patients with Erectile Dysfunction: An Open Label Phase I Clinical Trial. Urol Int. 2018;101(3):358-365. doi: 10.1159/000492120. Epub 2018 Aug 31. PMID: 30173210.
  3. Alipour M, Nabavi SM, Arab L, Vosough M, Pakdaman H, Ehsani E, Shahpasand K. Stem cell therapy in Alzheimer's disease: possible benefits and limiting drawbacks. Mol Biol Rep. 2019 Feb;46(1):1425-1446. doi: 10.1007/s11033-018-4499-7. Epub 2018 Dec 18. PMID: 30565076.
  4. Bahk JY, Jung JH, Han H, Min SK, Lee YS. Treatment of diabetic impotence with umbilical cord blood stem cell intracavernosal transplant: preliminary report of 7 cases. Exp Clin Transplant. 2010 Jun;8(2):150-60. PMID: 20565373.
  5. Barczewska M, Maksymowicz S, Zdolińska-Malinowska I, Siwek T, Grudniak M. Umbilical Cord Mesenchymal Stem Cells in Amyotrophic Lateral Sclerosis: an Original Study. Stem Cell Rev Rep. 2020 Oct;16(5):922-932. doi: 10.1007/s12015-020-10016-7. PMID: 32725316; PMCID: PMC7456414
  6. Belingheri M, Lazzari L, Parazzi V, Groppali E, Biagi E, Gaipa G, Giordano R, Rastaldi MP, Croci D, Biondi A, Rebulla P, Edefonti A, Ghio L. Allogeneic mesenchymal stem cell infusion for the stabilization of focal segmental glomerulosclerosis. Biologicals. 2013 Nov;41(6):439-45. doi: 10.1016/j.biologicals.2013.09.004. Epub 2013 Oct 14. PMID: 24135082.  
  7. Bradstreet JJ, Sych N, Antonucci N, Klunnik M, Ivankova O, Matyashchuk I, Demchuk M, Siniscalco D. Efficacy of fetal stem cell transplantation in autism spectrum disorders: an open-labeled pilot study. Cell Transplant. 2014;23 Suppl 1:S105-12. doi: 10.3727/096368914X684916. Epub 2014 Oct 9. PMID: 25302490.
  8. Brazzini A, Cantella R, De la Cruz A, Yupanqui J, León C, Jorquiera T, Brazzini M, Ortega M, Saenz LN. Intraarterial autologous implantation of adult stem cells for patients with Parkinson disease. J Vasc Interv Radiol. 2010 Apr;21(4):443-51. doi: 10.1016/j.jvir.2010.01.008. Erratum in: J Vasc Interv Radiol. 2010 Jul;21(7):1141. PMID: 20346882.
    Lige L, Zengmin T. Transplantation of Neural Precursor Cells in the Treatment of Parkinson Disease: An Efficacy and Safety Analysis. Turk Neurosurg. 2016;26(3):378-83. doi: 10.5137/1019-5149.JTN.10747-14.4. PMID: 27161464.
  9. Bydon M, Dietz AB, Goncalves S, Moinuddin FM, Alvi MA, Goyal A, Yolcu Y, Hunt CL, Garlanger KL, Del Fabro AS, Reeves RK, Terzic A, Windebank AJ, Qu W. CELLTOP Clinical Trial: First Report From a Phase 1 Trial of Autologous Adipose Tissue-Derived Mesenchymal Stem Cells in the Treatment of Paralysis Due to Traumatic Spinal Cord Injury. Mayo Clin Proc. 2020 Feb;95(2):406-414. doi: 10.1016/j.mayocp.2019.10.008. Epub 2019 Nov 27. PMID: 31785831.
  10. Carstens MH, Gómez A, Cortés R, Turner E, Pérez C, Ocon M, Correa D. Non-reconstructable peripheral vascular disease of the lower extremity in ten patients treated with adipose-derived stromal vascular fraction cells. Stem Cell Res. 2017 Jan;18:14-21. doi: 10.1016/j.scr.2016.12.001. Epub 2016 Dec 8. PMID: 27984756.
  11. Centeno CJ, Schultz JR, Cheever M, Freeman M, Robinson B, et al. (2011) A Case Series of Percutaneous Treatment of Non-Union Fractures with Autologous, Culture Expanded, Bone MarrowDerived, Mesenchymal Stem Cells and Platelet Lysate. J Bioengineer & Biomedical Sci S2:007.doi:10.4172/2155-9538.S2-007
  12. Cheng H, Liu X, Hua R, Dai G, Wang X, Gao J, An Y. Clinical observation of umbilical cord mesenchymal stem cell transplantation in treatment for sequelae of thoracolumbar spinal cord injury. J Transl Med. 2014 Sep 12;12:253. doi: 10.1186/s12967-014-0253-7. PMID: 25209445; PMCID: PMC4172930.
  13. Connick P, Kolappan M, Crawley C, Webber DJ, Patani R, Michell AW, Du MQ, Luan SL, Altmann DR, Thompson AJ, Compston A, Scott MA, Miller DH, Chandran S. Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study. Lancet Neurol. 2012 Feb;11(2):150-6. doi: 10.1016/S1474-4422(11)70305-2. Epub 2012 Jan 10. PMID: 22236384; PMCID: PMC3279697.
  14. Christopher D Riemann, Eyal Banin, Adiel Barak, David S Boyer, Rita Ehrlich, Tareq Jaouni, Richard McDonald, David Telander, Michael Keane, Jessica Ackert, Mark D. Ferguson, Avi Ben- Shabat, Jordi Mones, Diana Angelini, Gary S. Hogge, Benjamin Reubinoff; Phase I/IIa Clinical Trial of Human Embryonic Stem Cell (hESC)-Derived Retinal Pigmented Epithelium (RPE, OpRegen) Transplantation in Advanced Dry Form Age-Related Macular Degeneration (AMD): Interim Results. Invest. Ophthalmol. Vis. Sci. 2020;61(7):865.
  15. da Cruz L, Fynes K, Georgiadis O, Kerby J, Luo YH, Ahmado A, Vernon A, Daniels JT, Nommiste B, Hasan SM, Gooljar SB, Carr AF, Vugler A, Ramsden CM, Bictash M, Fenster M, Steer J, Harbinson T, Wilbrey A, Tufail A, Feng G, Whitlock M, Robson AG, Holder GE, Sagoo MS, Loudon PT, Whiting P, Coffey PJ. Phase 1 clinical study of an embryonic stem cell-derived retinal pigment epithelium patch in age-related macular degeneration. Nat Biotechnol. 2018 Apr;36(4):328-337. doi: 10.1038/nbt.4114. Epub 2018 Mar 19. PMID: 29553577.
  16. Dai G, Liu X, Zhang Z, Yang Z, Dai Y, Xu R. Transplantation of autologous bone marrow mesenchymal stem cells in the treatment of complete and chronic cervical spinal cord injury. Brain Res. 2013 Oct 2;1533:73-9. doi: 10.1016/j.brainres.2013.08.016. Epub 2013 Aug 12. PMID: 23948102.
  17. Dawson G, Sun JM, Davlantis KS, Murias M, Franz L, Troy J, Simmons R, Sabatos-DeVito M, Durham R, Kurtzberg J. Autologous Cord Blood Infusions Are Safe and Feasible in Young Children with Autism Spectrum Disorder: Results of a Single-Center Phase I Open-Label Trial. Stem Cells Transl Med. 2017 May;6(5):1332-1339. doi: 10.1002/sctm.16-0474. Epub 2017 Apr 5. PMID: 28378499; PMCID: PMC5442708.
  18. Desai P, Hasan SM, Zambrana L, Hegde V, Saleh A, Cohn MR, Lane JM. Bone Mesenchymal Stem Cellswith Growth Factors Successfully Treat Nonunions and Delayed Unions. HSS J. 2015 Jul;11(2):104-11.doi: 10.1007/s11420-015-9432-1. Epub 2015 Mar 25. PMID: 26140028; PMCID: PMC4481261.
  19. Dubsky M, Jirkovska A, Bem R, Fejfarova V, Pagacova L, Sixta B, Varga M, Langkramer S, Sykova E, Jude EB. Both autologous bone marrow mononuclear cell and peripheral blood progenitor cell therapies similarly improve ischaemia in patients with diabetic foot in comparison with control treatment. Diabetes Metab Res Rev. 2013 Jul;29(5):369-76. doi: 10.1002/dmrr.2399. PMID: 23390092.  
  20. Forbes GM, Sturm MJ, Leong RW, Sparrow MP, Segarajasingam D, Cummins AG, Phillips M, Herrmann RP. A phase 2 study of allogeneic mesenchymal stromal cells for luminal Crohn's disease refractory to biologic therapy. Clin Gastroenterol Hepatol. 2014 Jan;12(1):64-71. doi: 10.1016/j.cgh.2013.06.021. Epub 2013 Jul 19. PMID: 23872668.
  21. Garber MG and Carlos ND. Intracavernous administration of adipose stem cells: a new technique of treating erectile dysfunction in diabetic patient, preliminary report of 6 cases. MOJ Cell Sci Rep. 2015;2(1):5-8.
  22. Geffner LF, Santacruz P, Izurieta M, Flor L, Maldonado B, Auad AH, Montenegro X, Gonzalez R, Silva F. Administration of autologous bone marrow stem cells into spinal cord injury patients via multiple routes is safe and improves their quality of life: comprehensive case studies. Cell Transplant. 2008;17(12):1277-93. doi: 10.3727/096368908787648074. PMID: 19364066.
  23. Ghoryani M, Shariati-Sarabi Z, Tavakkol-Afshari J, Ghasemi A, Poursamimi J, Mohammadi M. Amelioration of clinical symptoms of patients with refractory rheumatoid arthritis following treatment with autologous bone marrow-derived mesenchymal stem cells: A successful clinical trial in Iran. Biomed Pharmacother. 2019 Jan;109:1834-1840. doi: 10.1016/j.biopha.2018.11.056. Epub 2018 Nov 26. PMID: 30551438.
  24. Golpanian S, DiFede DL, Khan A, et al. Allogeneic Human Mesenchymal Stem Cell Infusions for Aging Frailty. J Gerontol A Biol Sci Med Sci. 2017;72(11):1505-1512. doi:10.1093/gerona/glx056
  25. Guillaume-Jugnot P, Daumas A, Magalon J, Jouve E, Nguyen PS, Truillet R, Mallet S, Casanova D,Giraudo L, Veran J, Dignat-George F, Sabatier F, Magalon G, Granel B. Autologous adipose-derivedstromal vascular fraction in patients with Scleroderma: 12-month follow-up. Rheumatology (Oxford).2016 Feb;55(2):301-6. doi: 10.1093/rheumatology/kev323. Epub 2015 Sep 8. PMID: 26350489.
  26. Gu F, Wang D, Zhang H, Feng X, Gilkeson GS, Shi S, Sun L. Allogeneic mesenchymal stem cell transplantation for lupus nephritis patients refractory to conventional therapy. Clin Rheumatol. 2014 Nov;33(11):1611-9. doi: 10.1007/s10067-014-2754-4. Epub 2014 Aug 14. PMID: 25119864.
  27. Hare JM, Traverse JH, Henry TD, Dib N, Strumpf RK, Schulman SP, Gerstenblith G, DeMaria AN, Denktas AE, Gammon RS, Hermiller JB Jr, Reisman MA, Schaer GL, Sherman W. A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction. J Am Coll Cardiol. 2009 Dec 8;54(24):2277-86. doi: 10.1016/j.jacc.2009.06.055. PMID: 19958962; PMCID: PMC3580848.
  28. Haahr MK, Jensen CH, Toyserkani NM, Andersen DC, Damkier P, Sørensen JA, Lund L, Sheikh SP. Safety and Potential Effect of a Single Intracavernous Injection of Autologous Adipose-Derived Regenerative Cells in Patients with Erectile Dysfunction Following Radical Prostatectomy: An Open-Label Phase I Clinical Trial. EBioMedicine. 2016 Jan 19;5:204-10. doi: 10.1016/j.ebiom.2016.01.024. PMID: 27077129; PMCID: PMC4816754.
  29. Hu J, Yu X, Wang Z, Wang F, Wang L, Gao H, Chen Y, Zhao W, Jia Z, Yan S, Wang Y. Long term effectsof the implantation of Wharton's jelly-derived mesenchymal stem cells from the umbilical cord for newlyonset type 1 diabetes mellitus. Endocr J. 2013;60(3):347-57. doi: 10.1507/endocrj.ej12-0343. Epub 2012Nov 16. PMID: 23154532.
  30. Hu J, Zhao G, Zhang L, Qiao C, Di A, Gao H, Xu H. Safety and therapeutic effect of mesenchymal stem cell infusion on moderate to severe ulcerative colitis. Exp Ther Med. 2016 Nov;12(5):2983-2989. doi: 10.3892/etm.2016.3724. Epub 2016 Sep 20. PMID: 27882104; PMCID: PMC5103734.
  31. Hur JW, Cho TH, Park DH, Lee JB, Park JY, Chung YG. Intrathecal transplantation of autologous adipose-derived mesenchymal stem cells for treating spinal cord injury: A human trial. J Spinal Cord Med. 2016 Nov;39(6):655-664. doi: 10.1179/2045772315Y.0000000048. Epub 2015 Jul 24. PMID: 26208177; PMCID: PMC5137573.
  32. Jiang R, Han Z, Zhuo G, Qu X, Li X, Wang X, Shao Y, Yang S, Han ZC. Transplantation of placentaderived mesenchymal stem cells in type 2 diabetes: a pilot study. Front Med. 2011 Mar;5(1):94-100. doi:10.1007/s11684-011-0116-z. Epub 2011 Mar 17. PMID: 21681681.
  33. Karussis D, Karageorgiou C, Vaknin-Dembinsky A, Gowda-Kurkalli B, Gomori JM, Kassis I, Bulte JW, Petrou P, Ben-Hur T, Abramsky O, Slavin S. Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosis. Arch Neurol. 2010 Oct;67(10):1187-94. doi: 10.1001/archneurol.2010.248. PMID: 20937945; PMCID: PMC3036569.
  34. Kahraman NS, Oner A. Umbilical cord derived mesenchymal stem cell implantation in retinitis pigmentosa: a 6-month follow-up results of a phase 3 trial. Int J Ophthalmol. 2020;13(9):1423-1429. Published 2020 Sep 18. doi:10.18240/ijo.2020.09.14.
  35. Kim HY, Kim H, Oh KW, Oh SI, Koh SH, Baik W, Noh MY, Kim KS, Kim SH. Biological markers of mesenchymal stromal cells as predictors of response to autologous stem cell transplantation in patients with amyotrophic lateral sclerosis: an investigator-initiated trial and in vivo study. Stem Cells. 2014 Oct;32(10):2724-31. doi: 10.1002/stem.1770. PMID: 24966156.
  36. Lasala GP, Silva JA, Minguell JJ. Therapeutic angiogenesis in patients with severe limb ischemia by transplantation of a combination stem cell product. J Thorac Cardiovasc Surg. 2012 Aug;144(2):377-82. doi: 10.1016/j.jtcvs.2011.08.053. Epub 2011 Nov 12. PMID: 22079876. 
  37. Le Thi Bich P, Nguyen Thi H, Dang Ngo Chau H, Phan Van T, Do Q, Dong Khac H, Le Van D, Nguyen Huy L, Mai Cong K, Ta Ba T, Do Minh T, Vu Bich N, Truong Chau N, Van Pham P. Allogeneic umbilical cord-derived mesenchymal stem cell transplantation for treating chronic obstructive pulmonary disease: a pilot clinical study. Stem Cell Res Ther. 2020 Feb 13;11(1):60. doi: 10.1186/s13287-020-1583-4. PMID: 32054512; PMCID: PMC7020576.
  38. Li A, Tao Y, Kong D, Zhang N, Wang Y, Wang Z, Wang Y, Wang J, Xiao J, Jiang Y, Liu X, Zheng C. Infusion of umbilical cord mesenchymal stem cells alleviates symptoms of ankylosing spondylitis. Exp Ther Med. 2017 Aug;14(2):1538-1546. doi: 10.3892/etm.2017.4687. Epub 2017 Jun 27. PMID: 28781629; PMCID: PMC5526206.
  39. Li JF, Zhang DJ, Geng T, Chen L, Huang H, Yin HL, Zhang YZ, Lou JY, Cao B, Wang YL. The potential of human umbilical cord-derived mesenchymal stem cells as a novel cellular therapy for multiple sclerosis. Cell Transplant. 2014;23 Suppl 1:S113-22. doi: 10.3727/096368914X685005. Epub 2014 Nov 5. PMID: 25385295.
  40. Liang J, Zhang H, Hua B, Wang H, Lu L, Shi S, Hou Y, Zeng X, Gilkeson GS, Sun L. Allogenic mesenchymal stem cells transplantation in refractory systemic lupus erythematosus: a pilot clinical study. Ann Rheum Dis. 2010 Aug;69(8):1423-9. doi: 10.1136/ard.2009.123463. Erratum in: Ann Rheum Dis. 2011 Jan;70(1):237. PMID: 20650877.
  41. Liang J, Zhang H, Zhao C, Wang D, Ma X, Zhao S, Wang S, Niu L, Sun L. Effects of allogeneic mesenchymal stem cell transplantation in the treatment of liver cirrhosis caused by autoimmune diseases. Int J Rheum Dis. 2017 Sep;20(9):1219-1226. doi: 10.1111/1756-185X.13015. Epub 2017 Feb 20. PMID: 28217916.
  42. Limoli PG, Limoli C, Vingolo EM, Franzone F, Nebbioso M. Mesenchymal stem and non-stem cell surgery, rescue, and regeneration in glaucomatous optic neuropathy. Stem Cell Res Ther. 2021 May 6;12(1):275. doi: 10.1186/s13287-021-02351-4. PMID: 33957957; PMCID: PMC8101217.
  43. Lv YT, Zhang Y, Liu M, Qiuwaxi JN, Ashwood P, Cho SC, Huan Y, Ge RC, Chen XW, Wang ZJ, Kim BJ, Hu X. Transplantation of human cord blood mononuclear cells and umbilical cord-derived mesenchymal stem cells in autism. J Transl Med. 2013 Aug 27;11:196. doi: 10.1186/1479-5876-11-196. PMID: 23978163; PMCID: PMC3765833.
  44. Mendonça MV, Larocca TF, de Freitas Souza BS, Villarreal CF, Silva LF, Matos AC, Novaes MA, Bahia CM, de Oliveira Melo Martinez AC, Kaneto CM, Furtado SB, Sampaio GP, Soares MB, dos Santos RR. Safety and neurological assessments after autologous transplantation of bone marrow mesenchymal stem cells in subjects with chronic spinal cord injury. Stem Cell Res Ther. 2014 Nov 17;5(6):126. doi: 10.1186/scrt516. PMID: 25406723; PMCID: PMC4445989.
  45. Miyagawa S, Domae K, Yoshikawa Y, Fukushima S, Nakamura T, Saito A, Sakata Y, Hamada S, Toda K, Pak K, Takeuchi M, Sawa Y. Phase I Clinical Trial of Autologous Stem Cell-Sheet Transplantation Therapy for Treating Cardiomyopathy. J Am Heart Assoc. 2017 Apr 5;6(4):e003918. doi: 10.1161/JAHA.116.003918. PMID: 28381469; PMCID: PMC5532985.
  46. Nassar W, El-Ansary M, Sabry D, Mostafa MA, Fayad T, Kotb E, Temraz M, Saad AN, Essa W, Adel H. Umbilical cord mesenchymal stem cells derived extracellular vesicles can safely ameliorate the progression of chronic kidney diseases. Biomater Res. 2016 Aug 5;20:21. doi: 10.1186/s40824-016-0068-0. Erratum in: Biomater Res. 2017 Apr 6;21:3. PMID: 27499886; PMCID: PMC4974791.  
  47. Nguyen Thanh L, Nguyen HP, Ngo MD, Bui VA, Dam PTM, Bui HTP, Ngo DV, Tran KT, Dang TTT, Duong BD, Nguyen PAT, Forsyth N, Heke M. Outcomes of bone marrow mononuclear cell transplantation combined with interventional education for autism spectrum disorder. Stem Cells Transl Med. 2021 Jan;10(1):14-26. doi: 10.1002/sctm.20-0102. Epub 2020 Sep 9. PMID: 32902182; PMCID: PMC7780798.
  48. Oh KW, Noh MY, Kwon MS, Kim HY, Oh SI, Park J, Kim HJ, Ki CS, Kim SH. Repeated Intrathecal Mesenchymal Stem Cells for Amyotrophic Lateral Sclerosis. Ann Neurol. 2018 Sep;84(3):361-373. doi: 10.1002/ana.25302. Epub 2018 Aug 31. PMID: 30048006; PMCID: PMC6175096
  49. Oner A, Gonen ZB, Sevim DG, Smim Kahraman N, Unlu M. Suprachoroidal Adipose Tissue-Derived Mesenchymal Stem Cell Implantation in Patients with Dry-Type Age-Related Macular Degeneration and Stargardt's Macular Dystrophy: 6-Month Follow-Up Results of a Phase 2 Study. Cell Reprogram. 2018 Dec;20(6):329-336. doi: 10.1089/cell.2018.0045. PMID: 31251672.
  50. Özmert E, Arslan U. Management of retinitis pigmentosa by Wharton's jelly derived mesenchymal stem cells: preliminary clinical results. Stem Cell Res Ther. 2020 Jan 13;11(1):25. doi: 10.1186/s13287-020-1549-6. PMID: 31931872; PMCID: PMC6958670.
  51. Prabhakar S, Marwaha N, Lal V, Sharma RR, Rajan R, Khandelwal N. Autologous bone marrow-derived stem cells in amyotrophic lateral sclerosis: a pilot study. Neurol India. 2012 Sep-Oct;60(5):465-9. doi: 10.4103/0028-3886.103185. PMID: 2313502.
  52. Petrou P, Gothelf Y, Argov Z, Gotkine M, Levy YS, Kassis I, Vaknin-Dembinsky A, Ben-Hur T, Offen D, Abramsky O, Melamed E, Karussis D. Safety and Clinical Effects of Mesenchymal Stem Cells Secreting Neurotrophic Factor Transplantation in Patients With Amyotrophic Lateral Sclerosis: Results of Phase 1/2 and 2a Clinical Trials. JAMA Neurol. 2016 Mar;73(3):337-44. doi: 10.1001/jamaneurol.2015.4321. PMID: 26751635.
  53. Petrou P, Kassis I, Levin N, Paul F, Backner Y, Benoliel T, Oertel FC, Scheel M, Hallimi M, Yaghmour N, Hur TB, Ginzberg A, Levy Y, Abramsky O, Karussis D. Beneficial effects of autologous mesenchymal stem cell transplantation in active progressive multiple sclerosis. Brain. 2020 Dec 1;143(12):3574-3588. doi: 10.1093/brain/awaa333. PMID: 33253391.
  54. Protogerou V, Michalopoulos E, Mallis P, et al. Administration of Adipose Derived Mesenchymal Stem Cells and Platelet Lysate in Erectile Dysfunction: A Single Center Pilot Study. Bioengineering (Basel). 2019;6(1):21. Published 2019 Mar 5. doi:10.3390/bioengineering6010021.
  55. Protogerou V, Beshari SE, Michalopoulos E, Mallis P, Chrysikos D, Samolis AA, Stavropoulos-Giokas C, Troupis T. The Combined Use of Stem Cells and Platelet Lysate Plasma for the Treatment of Erectile Dysfunction: A Pilot Study-6 Months Results. Medicines (Basel). 2020 Mar 18;7(3):14. doi: 10.3390/medicines7030014. PMID: 32197323; PMCID: PMC7151592.
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Suplementación intravenosa (IV Drips)

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